Yeast Consuting Services

Fungus Related Disease Questionnaire-7 (FRDQ-7)


SUMMARY: The following seven questions correlated with improvement after nystatin therapy in a controlled clinical study of the yeast syndrome by Santelmann et al. (2001). Patients first filled out the popular 70-item questionnaire published by Crook (1995), and were then treated with nystatin. Answers from patients who improved were compared to answers from patients who did not respond to therapy in a gradual statistical discrimination analysis. The statisticians concluded that only seven questions from the original 70-item questionnaire predicted a positive response to nystatin in 95% of the patients. The final list of seven questions below is a scientifically validated screening tool, not a diagnostic test. It is useful for identifying possible yeast syndrome patients for laboratory testing. These findings underscore the importance of doing controlled clinical studies to establish standards of medical care. Hopefully, in the years to come, more physicians will accept the fact that fungus-related disease symptoms merit diagnostic evaluation and appropriate treatment based on test results.

SCORE:             0 = none
                        1 = occasional or mild
                        2 = frequent or moderately severe
                        3 = severe or disabling

1.   Have you, at any time in your life, taken broad spectrum antibiotics?                 0 or 3

2.   Have you taken tetracycline or other broad spectrum antibiotics for
      one month or longer?                                                                                  0 or 3

3.   Are your symptoms worse on damp, muggy days or in moldy places?               0 or 3

4.   Do you crave sugar?                                                                                    0 or 3

5.   Do you have a feeling of being "drained?”                                               0, 1, 2 or 3

6.   WOMEN:  Are you bothered with vaginal burning, itching or discharge?     0, 1, 2 or 3

      MEN:  Do you have burning, itching or discharge from the penis?             0, 1, 2 or 3

7.   Are you bothered by burning, itching or tearing of your eyes?                  0, 1, 2 or 3

TOTAL SCORE FOR FRDQ-7:                 
Score     0-3   =   FRD unlikely
Score     4-9   =   FRD probable
Score 10-21  =   FRD almost certain

Is the patient positive for FRD or the yeast syndrome?                  Circle one:   NO   YES


Crook, W.G. (1995) The Yeast Connection and the Woman, Professional Books, Inc., Jackson, Tennessee. SURVEY ONLINE: Go to and click on “Dr. Crook’s Famous Yeast Evaluation Questionnaire” to download yeastfullsurv.pdf.

Santelmann, H., Lærum, E., Rønnevig, J. and Fagertun, H.E. (2001) Effectiveness of nystatin in polysymptomatic patients. A randomized, double-blind trial with nystatin versus placebo in general practice. Family Practice 18 (3): 258-265. REPRINT ONLINE: Go to and click on PDF article to download Santelmann_Family%20Practice.pdf.

When you call Dr. Crandall for a Phone Consult, tell her your score on FRDQ-7.

Typical symptoms and test results for a yeast syndrome patient are discussed in Step 1 of the TEN STEP PROGRAM in the Information Packet.

Copyright, 2008, Marjorie Crandall, Ph.D.


Copyright, 1996 to 2008, Marjorie Crandall, Ph.D.

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